PlatformsneuroGENOMICS & neuroPROTEOMICS

Click Here for the Neuroproteomics & Neurogenomics Platform Leaders Report 2003/2004

 

 

Contact

Tiffany Cowie
Platform Manager
P (+613) 8344 3438
M 0418 373 073
F (+613) 9348 2952
Email platform-enquiries@unimelb.edu.au


Access to services allowing the examination and profiling of gene and protein expression, and to techniques identifying genetic susceptibility to neurological and psychological conditions
With the increasingly holistic approach of neuroscientific analysis, successful participation in competitive scientific environments requires access to, and integration of, emerging technologies.
The neuroProteomics and neuroGenomics (P&G) Platform has been established under the leadership of Professor Colin Masters to provide these technical capabilities through a single interface, and harnesses Victoria's leading intellectual capital in neuroscientific proteomic and genomic analysis.

Accessing the P&G Platform is easy, efficient and very cost-effective; please contact Tiffany Cowie for further information, or to discuss Platform solutions to your research questions.

Objectives
The P&G Platform aims to coordinate and integrate existing Victorian capabilities to provide the neuroscience community with:
National access to core facilities that undertake gene discovery, mutation detection, protein identification and structural studies
Collaborative engagement in structural and functional proteomics/genomics
Expertise and training through consultation, education, experimental design and implementation
Generation of commercially-exploitable IP by the discovery and elucidation of gene/protein function
Impletementation of a system of cost-recovery that allows the Services Platform to be self funding.


Facilities and Expertise
Proteomics Services
2-Dimentional gel electrophoresis
Protein Expression
Mass spectrometry (MALDI-TOF)
Chromatography


The P& G Platform also possesses the capabilities for evaluation of protein chemistry and drug interactions, and application of the above findings to clinical trials, leveraging associations across NNF Platforms.

Genomics services
DNA Microarray analysis
In Situ Hybridisation
Restriction Fragment Length Polymorphism (RFLP)
Serial Analysis of Gene Expression (SAGE)
Denaturing High Performance Liquid Chromatography (DHPLC)
Genetic Diagnostics
DNA sequencing and genotyping

P&G facilities also allow the creation of databases & computer robotics systems for rapid tissue scanning in order to determine disease-causing genes.

Bioinformatics services
The P&G Platform offers the expertise of Dr Victoria Perreau for assistance with experimental design and expression data analysis.
The Platform's bioinformatics consultation also enables access to advanced software tools, broad collaborative bioinformatics networks, and can be bundled with Affymetrix gene expression studies in collaboration with The Australian Genome Research Facility Ltd.


P&G Development Projects
Protein array technology
Neuroscientific mutation database

 

Links

Monash Biomedical Proteomics Facility
Platform Service Presentation August 2005


Key Personnel
Name Organisation Expertise
Prof Colin Masters

The Department of Pathology,
The University of Melbourne

 Platform Leader
Prof Richard Cotton Genomic Disorders Research Centre Mutation detection and documentation systems
Prof Brian Dean Mental Health Research Institute RFLP, structural biology
Prof Ian Smith

Department of Biochemistry
Monash University

 Structural biology
Prof Geoff Tregear The Howard Florey Institute Structural biology
Assoc Prof Seong-Seng Tan The Howard Florey Institute SAGE
Assoc Prof Deon Venter Murdoch Children's Research Institute DNA microarrays
Dr Feda Ali P&G Platform
The University of Melbourne		 HPLC
Dr Roberto Cappai The Department of Pathology
The University of Melbourne		 Structural biology
Dr Steven Bottomley Department of Biochemistry & Molecular Biology
Monash University		 Protein expression
Dr David Steer

P&G Platform
Monash University

 Gel and LC protein separation
Dr Tony White Department of Pathology
The University of Melbourne		 Protein Arrays
Dr Victoria Perreau P&G Platform &
The Centre for Neuroscience		 Bioinformatics
Mr Tai Du P&G Platform
The University of Melbourne		 Protein Arrays
Ms Tiffany Cowie

Department of Pathology
The University of Melbourne

 Platform Manager, Genetic Analysis


 
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